Genetic and epigenetic aberrations across the human genome result in deregulation of critical gene networks and signaling pathways in disease. This symposium aims to highlight genomic and epigenomic technologies, integrative analytical approaches, relevant model organisms, and recent translational findings to identify biologically-significant and clinically translatable disease drivers. Presentations at this symposium will emphasize novel epigenomic and genomic insights in the context of cancer and other chronic diseases and provide a forum for future collaboration across the region. The symposium will be of interest to basic, translational, and clinical researchers and physicians from academia and industry working at the translational interface.