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2024 FEATURED SPEAKERS

Adrian Dubuc, PhD

Vice Chairperson, Department of Pathology

Roswell Park Comprehensive Cancer Center, Buffalo, NY

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Professor, Pharmacology & Toxicology

R. Ken & Conna Coit Endowed Chair in Aginig & Neurodegenerative Diseases

The University of Arizona, R. Ken Coit College of Pharmacy, Phoenix, AZ

Dr. Lemos' lab currently collaborates in projects examining human populations in China, Bangladesh, and the USA, as well as experimental studies in cell systems and model organisms. He focuses on the rDNA and the impact of dietary interventions and exposure to environmental toxicants on the genome and epigenome. He has recently developed the first long-range interaction map of the rDNA using Hi-C technology as well as developed the rDNA aging clock, an evolutionarily conserved marker of aging that is applicable to humans, mice, and other mammals. The rDNA clock can address chronological age in individuals of unknown age as well as biological age in response to interventions and toxicants. He has been awarded an Ellison Foundation New Scholars in Aging Award and a Smith Family Award for Excellence in Biomedical Research. 

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Professor & Chair, Department Pharmaceutical Sciences

University at Buffalo School of Pharmacy & Pharmaceutical Sciences, Buffalo, NY

Research interest areas:
Integrative and Systems Pharmacology of Anti-Platelet and Anti-Cancer Drugs

 

Development and experimental validation of quantitative structure-pharmacokinetic/pharmacodynamic (PK/PD) relationships (QSPR) to optimize drug design, development, and therapeutic application of anti-cancer compounds.
 

Integration of QSPR and mechanistic PD models developed with several drugs to predict in vivo PK/PD profiles of chemically related compounds.

Development of models of pharmacological target-mediated drug disposition and dynamics, and the experimental validation of the primary determinants of PK/PD profiles of drugs that exhibit such phenomena.

Development of non-deterministic models such as neural networks, alone or in combination with traditional adaptive feedback control methods, for individual optimization of complex pharmacotherapeutic regimens.

Incorporation of biomedical signal processing tools into PK/PD models for characterizing the pharmacology of drugs that alter spontaneous variability of signals of the cardiovascular and autonomic nervous systems

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Chief, Department of Clinical Genomics

Roswell Park Comprehensive Cancer Center, Buffalo, NY

Dr. Onel has spent his career as a clinical cancer geneticist caring for children, adults, and families at high risk for cancer due to genetic predispositions or family history. As a scientist, he is known internationally for his work on the genetic contribution to cancer risk and response to therapy, and is recognized as a leader in functional genomics, an emerging field integrating genetic and laboratory investigations that is yielding profound new insights into human health and disease.

Dean, Gerstner Sloan Kettering Graduate School

Memorial Sloan Kettering Cancer Center, New York, NY

Dr. Overholtzer's lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as macropinocytosis, and mechanisms of cell death. They investigate cell death mechanisms that have unique effects on cell populations, including entosis that supports the survival of starved cells and promotes cell competition, and ferroptosis that eliminates starved cell populations by propagating from cell to cell. The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis.

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Associate Director, Translation Genetics in Paediatric Laboratory Medicine

Hospital for Sick Children (SickKids)

Dr. Shlien's research uses the tools of modern sequence-based genomics to discover the mutations that are present in the genomes of paediatric cancer patients, and to understand how these mutations alter the somatic transcriptome.

Profesor, Department of Biomedical Genetics

Wilmot Distinguished Professorship in Cancer Genomics

University of Rochester Medicine, Rochester, NY

Dr. Vertino's research interests are focused on the areas of cancer epigenetics and novel mechanisms of gene silencing in cancer.

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Associate Profesor, Department of Pharmacology & Therapeutics

Roswell Park Comprehensive Cancer Center, Buffalo, NY

Dr. Woloszynka's research interests are focused on gene regulation, genetics and epigenetics, epigentic therapies, functional genomics, translational research, health disparities, bladder cancer and prostate cancer.

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